ABSTRACT
Objective To investigate the clinical value of C-reactive protein (CRP) combined with prothrombin time (PT) and partially activated thromboplastin time (APTY) in the diagnosis of neonatal late-onset sepsis.Methods From January 2013 to January 2018,100 neonates with sepsis admitted to our department of neonatology in Lishui Maternal and Child Health-Care Center were collected.According to the results of blood culture,neonates with positive blood culture were classified as sepsis group A (53 cases),and neonates with negative blood culture were classified as sepsis group B (47 cases).Another 50 normal newborns born at the same period were included in the control group.The CRP,PT and APTT values of the three groups were detected and compared.The receiver-operating characteristic curves (ROC) were plotted to obtain the area under ROC curve (AUC) and the sensitivity,specificity,positive predictive value and negative predictive value.Another ROC curve was plotted to obtain the area under ROC curve (AUC) and the sensitivity,specificity,positive predictive value,and negative predictive value for a new variable,CPR + PT + APTT,which was established using a binomial logistic regression method.Results The results of CPR,PT and APTT in the control group,sepsis group A and sepsis group B all increased in turn (F=10.616,6.155,5.243,P =0.000,0.000,0.000).CPR + PT + APTT had the largest AUC (0.94),the highest sensitivity (93.42％),the highest specificity (91.66％),the highest positive predictive value (92.60％),and the highest negative predictive value (78.55％) in the four indicators.Conclusion When blood culture fails to diagnose late-onset neonatal sepsis,combined detection of CPR + PT + APTT can provide some clues for its early diagnosis,which is worthy of clinical attention.
ABSTRACT
Objective To assess the age-specific sleep time among children 2 to 12 years of age in Yuexiu district,Guangzhou,China,and to identify the related factors.Methods 1734 children,aged 2 to 12 years were randomly selected from two elemental schools and two kindergartens in Yuexiu district of Guangzhou under strict quality control system,their parents were interviewed with questionnaire to look into their familial and social environment,as well as sleep related factors.Results The total sleep time among children less than 6 years of age in Yuexiu district,Guangzhou was less than that among children the same age in other provinces in China.The factors were related to children's inadequacy of total time included age,sleep problems,the history of sleep snoring in father and mother,feeding manners,difficulty at sleep onset.Conclusion The total sleep time among children at lower age in Yuexiu district,Guangzhou is on the low side.The main influencing factor of insufficiency of sleep time among children is the family environmental factors,the sleep time should be recognized by family and society.